British Law Essay Example | Topics and Well Written Essays - 2250 words

British Law - Essay Example This separate rule of law has made it possible for certain legal measures to be created in a balanced response to the needs and the demands of those individuals that are involved in certain considered situations. Besides that, the empowerment of the law is further aided through the effective separation of powers that the royalties and their subjects are under. Even though the entire European region answers to the central power of a royalty, the queen, they are still considered to be under very democratic governance in terms of realizing the society's freedom to do what they perceive to be rightfully lawful under the legal systems of the country. Why is this so Although the central command of the government comes from the queen, her subjects are the ones directly involved in the work3. There is even this thought that says "the queen reigns but the queen does not rule"; a particular line that dispenses the thought that the UK system of law does not rely only on one monarch's decision but that of her advisers who feed her with the ideas that conform to her beliefs, making possible changes in the society in case some adjustments need to be made. Democratic accountability is a huge consideration for the creators of the law. The people are free and ought to have their own rights even when dealing with the most serious issues in the society4. In every law, it is then recognized that the rights of the people are rightly realized and given proper attention to. Hence, from creating the law towards implementing it, it could be noticed how the UK government intends to give each individual the rightful cause of their being through providing them the respect and recognition of rights that they deserve to have. 2. Making reference to relevant case law, explain and critically examine the different approaches adopted by the courts in deciding whether a particular decision is unlawful on the ground of bias. The British court receives the greatest if not the highest recognition in the UK society. Standing as the judge of all, and the law implementation agent in the society, the British court is noted for its unbiased view of the people, both those who are in power and those who are not. The principle of the rule of law which suggests that "no one is above the law, even those who are in power" depicts a great fact that is recognized by the British court every time it handles cases that involves different parties having disagreements between each other5. This principle subjects everyone accountable to the law without any exceptions given. However, as it could be realized, humans make mistakes and the British court is ruled by human individuals and are thus expected to make mistakes every now and then but of course not all the time. No matter, the British court recognizes mistakes and definitely puts an end to it. The legal guidelines on investigating particular cases that involve ground bias provides a clearer explanation as to how agents of the law who becomes biased during a

The Apollo Group, Inc Case Study Example | Topics and Well Written Essays - 1000 words

The Apollo Group, Inc - Case Study Example Unlike other universities, UOP is a for-profit institution. Synopsis of the Situation The University of Phoenix catered to the working adults who wanted to continue their education. It was one of the first institutions to target this growing market. They are considered the giant in the industry and as such have earned $2.5 billion in revenues in 2006. While many colleges employed full-time faculty members, UOP hired working professionals as teachers. The success of the Apollo Group emanates from the fact that they were able to tap an unserved niche in the market, that is, the working adults. Key Issues The key issues of the case are the growing demand for online education not only in the US but also in the developing countries, the need to open up new local campuses and the need to improve the existing technology that UOP utilizes. Define the Problem The problem presented in the case is how to change the reputation of UOP from a â€Å"diploma mill† establishment to one which i s offers accredited degree programs and an institution that will introduce new undergraduate and graduate degree programs that will meet the needs of both the adult working population and the traditional collegiate market. Alternative Solutions There are several solutions that may be adapted by UOP namely: Use the media to give information about programs that they offer, the competence of their faculty members and the academic system that they use Highlight the low cost of tuition as compared to other colleges Create tie-ups with large corporations to encourage their employees to enroll at UOP; discounts may be given to corporations which enrolls a certain number of their workers at UOP Advertise through the internet to capture foreign markets and increase its student population Put emphasis on the concept of offering quality education at schedules that are accessible even to working adults Need to invest more on latest technology available for educational institutions especially wi th regards to online education Selected Solution to the Problem The selected solution to the problem is a combination of all the alternative solutions presented above. UOP cannot just rely on a single solution to its problems. It should improve its course and program offerings and hire more competent faculty members. It is also essential that UOP keep abreast with the latest technological advancements in the industry. After improving on the said aspects, it must allocate the necessary funds to come up with an advertising strategy that will improve its reputation by highlighting its unique selling point and emphasizing the quality of its education. Implementation The solutions suggested would take several months to implement. The first step to do is to research on the latest technology available for online education. This is of utmost importance because several schools are already offering online programs and if UOP does not adapt the latest technology, they might not be able to reta in its market leadership. The next step is to beef up its marketing to other developing countries. This should be done because in case they lose their leadership in the US market, the foreign market can augment any decline in enrollment in the local market. Expanding overseas is the way to go for online education. Hand in hand with marketing to the foreign market, UOP must recruit new faculty members to maintain the ratio of students to

Role Of Chromosome 21 In Alzheimers Disease Biology Essay

Role Of Chromosome 21 In Alzheimers Disease Biology Essay Down syndrome is a genetic disease that caused by trisomy of Human chromosome 21. Down syndrome is common chromosomal disorder of mental retardation in humans. It is caused by the three types of chromosomal abnormalities namely, free trisomy 21, translocation Down syndrome and mosaic Down syndrome. Most of the Down syndrome individuals experience Alzheimer-like neuropathology like dementia, neurofibrillary tangles and many others. Genes that are in Chromosome 21 which includes SOD-1, DSCR1, APP gene and S100B, are highly involved in the relationship between Down syndrome and Alzheimer disease. Besides the genes involved, other factors like oxidative stress and hormone will be discussed in this review too. There are two different types of hypotheses associated with Down syndrome namely, developmental instability and gene-dosage effect. Introduction Down syndrome is a common chromosomal disorder of mental retardation in humans. It is caused by the trisomy of chromosome 21. Down syndrome is named after John Laugdon Down in 1866.There is three different types of chromosomal abnormalities namely, free trisomy 21, translocation Down syndrome and mosaic Down syndrome. Over 90% of the time, non disjunction and failure to separate the chromosome pairs during meiosis are the principal cause of Down syndrome. Down syndrome is named after John Laugdon Down in 1866. The first person that published the relationship between Alzheimers disease-type neuropathology to clinical dementia in adults with Down syndrome was Jervis in 1948 and the person to demonstrate this disorder is due to the trisomy of chromosome 21 was by Jerome Lejeune in 1959. The symptoms associated with Down syndrome are diminished muscle tone, congenital heart disease, small skull, slanting eyes and retarded growth and development. Individuals with Down syndrome usually hav e the tendency of developing neuropathological changes like Alzheimer disease. Down syndrome has an overall incidence of 1 in 1000 live births when the mother aged 30, increasing 9 in 1000 births when the mother is aged 40 (Hook et al., 1983). Alzheimer disease is a neurodegenerative disease which maybe is found in Down syndrome individuals. This disease is named after a neuropathologist, Alois Alzheimer in 1906. Down syndrome individuals experience the Alzheimer-like neuropathology by their mid-40s. In the beginning, Alzheimer disease affects parts of brain like memory and languages. But after a period of time, this disease will progress and cause problems in all aspects of our life. Alzheimer disease has 2 forms, familial and sporadic forms. Familial Alzheimer disease is a rare disease which is genetically acquired. There are mainly 3 types of lesions that are observed in Alzheimer disease. It is then caused by the mutations in several genes like APP which will lead to the over production of the amyloid-beta protein. The most common form of Alzheimer disease is sporadic form which contributes to 90% of Alzheimer disease cases. The first type is the neuritic plaques, extracellular deposits of fibrillar beta amyloid surrou nded by degenerating neuronal processes and terminals. The next type of lesions is intraneuronal neurofibrillary tangles, primarily composed of abnormally hyperphospholated tau protein and lastly, it is vascular beta-amyloidosis associated with fibrillar amyloid deposition within the vascular wall. Over time, these pathological processes contribute to synaptic and neuronal loss, deterioration of neuronal networks, brain atrophy and dementia (Victor Ropper, 2001). Nowadays, people have longer life span and hence the Alzherimer disease become much more worrying for us as it will become a major public concern. There were 26.6 million of people that are suffering of the Alzheimer disease in 2006 and this number will continue to grow. It is then estimated to affect 1 in 85 people worldwide by the year of 2050. In fact, it was not until 1985 that research explicitly focused on aging related changes in health status and cognition of adults with intellectual disabilities, and in particular those with Down syndrome, began in earnest (Janicki et al, 1985). In Down syndrome, there are two different types of hypotheses associated namely, developmental instability and gene-dosage effect. The developmental instability hypothesis indicated that the correct balance of gene expression in the development is being disrupted. But this hypothesis is being questioned since other autosomal trisomy syndromes do not lead to the same clinical pattern (Shapiro et al,2001). In another case, the gene-dosage effect hypothesis, specific gene that is over expressed is responsible for the Down syndrome phenotypic abnormalities which indicated is trisomy of the Chromosome 21 (Delabar et al,1993). The Genes In chromosome 21, the most critical part that affects Down syndrome phenotype is the long arm(q) of chromosome 21. The critical region in chromosome 21 that is important to Alzheimer disease are amyloid precursor protein (APP) located at Chromosome 21q21.3 , superoxide dismutase gene (SOD-1) located at Chromosome 21q22.11, Beta-site APP-cleaving 2 enzyme (BACE2) located at Chromosome 21q22.3, carbonyl reductase (CBR) located at Chromosome 21q22.1 and cystathionine beta-synthase (CBS) located at Chromosome 21q22.3 . The critical region in chromosome 21 that is important to Down syndrome are glycinamide formyl transferase (GART) located at Chromosome 21q22.1, SOD-1, Cu2+/Zn2+ superoxide dismutase, beta subunit of S100 calcium-binding protein (S100B) located at Chromosome 21q22.3, Down syndrome critical region gene 1 (DSCR1) located at 21q22.3 and Intersectin 1 (ITSN1). The Amyloid precursor protein (APP) APP gene is located on human chromosome 21 and codes for a transmembrane protein that is expressed in both neurons and astrocytes. This gene is important in the relationship between Down syndrome and Alzheimer disease. Overexpression of APP gene will lead to the increase production of amyloid-beta protein which is the main protein component of senile plaque. The cause of the familial Alzheimer disease is by the mutation n the APP gene. The amyloid-beta protein is formed by the proteolytic cleavage of the large, type-1 integral membrane-spanning glycoprotein APP by secretases. It has two different pathways, the amyloidogenic pathway and the nonamyloidogenic pathway. The amyloidogenic pathway is beta-secretase cleaves APP to generate APPsB, a 100-kDa soluble NH2-terminal fragment and a 12-kDa membranebound carboxyl-terminal fragment. Hence, the nonamyloidogenic pathway is that cleaved within its amyloid-beta region (aminoacids 16-17), at the alpha-secretase cleavage site, to produce an N-terminal fragment, APPsa, and a C-terminal APP fragment of 83 amino acids (Kang et al,1987). In normal mechanism of the brain, there is stable distribution of beta-amyloid in the brain and this intracellular beta-amyloid is essentially in the entire life indicated that beta-amyloid within neurons represents a product of normal metabolism. The two most common species of beta-amyloid are AB40 and AB42. Beta-amyloid will start to accumulate during younger times and with increasing in age, the amount will progressively increase. During middle ages like 35 years, beta-amyloid associated neuropathology will accelerate tremendously. The soluble APP is the most toxic APP which can have neurotrophic activities and longer aggregating forms. The amyloid-beta protein at high concentration will lead to neurotoxic whereas at low concentration it can function as a neurotrophic factor. When amyloid-beta protein is oxidized, the solubility will decrease and hen will result in the accumulation of the intracellular microglial. This accumulation will increase the concentration of amyloid-beta protein and lead to more plaque formation. Amyloid-beta protein will also induce oxidative stress directly and activating microglia indirectly (Yankner et al, 1990). Although it has been a strong standing that amyloid-beta protein contributes to the Alzheimer disease but there is evidence that amyloid-beta protein is very useful in our body. Amyloid-beta protein provides an important role in both synapse and in synaptic structure-functional plasticity that underlie learning and memory (Koudinov et al, 2001). The autopsy studies in brains of older Down syndrome individuals showed that senile plaque and neurofibrillary tangles and in the brains and some indivuals show a much earlier onset. This maybe suggest that there is an apoptotic action happening and may result in the large amount of neuronal death in the brain. It has been studies to show that APP metabolism in involved in the peripheral tissues. Changes occurs in APP metabolism is noted in the platelets, lymphocytes and fibroblasts in both Down syndrome and Alzheimer disease individuals. This change in APP showed that there is two to three fold of increase plasma concentration in both amyloid-beta protein(1-40) and amyloid-beta protein(1-42) in Down syndrome individuals and also increase of mRNA of APP. The Beta-site APP-cleaving 2 enzyme (BACE2) BACE is a transmembrane aspartyl protease and has a second protein called BACE2 that is 55% identical to BACE.BACE2 has two active site motifs of aspartic protinases which are located at residues 93 to 96 of DTGS and residues 289 to 292 of DSGT. BACE2 has a minor cleavage site at the beta-site of APP and also a major cleavage in the beta-amyloid region that is close to the alpha-secretase site. BACE2 is said to contribute to the amyloid-beta protein production. Some authors investigate the expression of BACE2 in the frontal context of the Down syndrome patients and hence, the immunoreactivity of BACE2 in Down syndrome patients with Alzheimer disease and control is compared. The results show that in neurorofibrillary tangle-bearing neurons there is BACE2 but not in those Down syndrome patient without Alzheimer disease. So, this will give an indication that BACE2 contribute to the Alzheimer-type neuropathology of Down syndrome (Barbiero et al, 2002). In Alzheimer individual platelets, there is a significant amount of reduction in the BACE2 which suggest that this BACE2 cause increase Alzheimer neuropathology. The Down syndrome critical region gene 1 (DSCR1) and The Intersectin 1 (ITSN1) The DSCR1 gene is located at the human chromosome 21 and it encodes for the calcipressin 1 which inhibit calcineurin activity by interacting with calcineurin A. So, phosphorylation of calcipressin 1 will inhibit the activity of calcineurin and this will allow the control the half life of calcipressin by increasing its degradation. To protect the cells from getting damaged, negative feedback mechanism of DSCR1 gene should be activated. In brain, heart and skeletal muscle, the DSCR1 is highly expressed. It was shown that DSCR1 is over expressed in the individual brain of the Down syndrome fetuses and post mortem and for those Alzheimer disease individuals, they also showed DSCR1 mRNA levels to be two to three times higher than the control. Basically, overexpression of DSCR1 can affect two calcineurin-dependent pathways by blocking calcineurin activity. So, when there is an increase of DSCR1, it may disrupt endocytosis and the vesicle recycling because of the calcineurin-dependent dephosphin dephosphorylation. Next, the hyper The ITSN1gene is located in human chromosome 21 and it encodes for endocytic protein ITSN1. In this gene, there are two major mRNA transcripts which divided into 6kb and 11kb, short and long isoforms. These isoforms are expressed in the brain but in different cell types. It has been detected in western blotting that long form is neuronal specific while the short form is in glial cells and for those Down syndrome individual, there is an over expression of the long isoform in the brain. These genes are involved in the neruronal endocytosis in the pathology of the Down syndrome and Alzheimer disease. In neuronal endocytosis, it is very important for the neuronal repair and survival as the secretory vesicles need to be reuptake during the synaptic transmission after any neuronal damage. The Minibrain-Kinase Gene The gene minibrain-kinase maybe associated with Down syndrome. This gene is encoded to the Down syndrome critical region 21q22.2. There has been studies that showed that the over expression will cause congnitive impairments with Down syndrome and increases in apoptotic cell death and reduction in neuronal differentiation which altered neuronal plasticity and intellectual disability observed in Down syndrome (Murakami et al, 2006). The Immune System Astrocytes also play an important role in old Down syndrome patients brain. Upon activation in the brain of the Down syndrome patient, it will express more of the S100B, an astrocyte-derived neurite growth-promoting factor. S100B is associated in dystrophic neurite formation and in plaque evolution and also in neurofibrillary tangle evolution in Alzheimer disease. S100B is secreted by astrocytes and increase the intraneuronal free calcium levels and stimulates the growth of neuronal processes. In the studies of S100B, it showed that the number of astrocytes expressing S100B in Down syndrome patient was about twice as that to the controls of all ages. Another way to test for the relationship between Down syndrome and Alzheimer disease is by the complement cascade, C1q. C1q accumulates in amyloid-beta protein deposits in neurons within Down syndrome brain. In this case, the increase level of C1q will suggest that it is responsible for the acceleration phase of Alzheimer disease pathogenesis in Down syndrome patient (Stoltzner et al, 2000). The Oxidative Stress Another factor that is involved in both Alzheimer disease and Down syndrome is oxidative stress. As we all know that oxygen is very important for life but the byproducts are very harmful. These byproducts include reactive oxygen species like superoxide and hydroxyl and hydrogen peroxide and peroxynitrite (Andersen et al.,2004). The amyloid precursor protein and the cytoplasmic enzyme Cu2+/Zn2+ superoxide dismutase (SOD-1) are responsible for reactive oxygen species homeostasis. SOD-1 is responsible for the first line of antioxidant defense by catalyzing the dismutation of O2à ¢Ã¢â€š ¬Ã‚ ¢- to molecular oxygen (O2) and H2O2, which can be converted by catalase (CAT) and by (selenium-containing) glutathione peroxidase (GPX) to water. Since SOD-1 is located at chromosome 21, so the trisomy of chromosome 21 will lead to accumulation of hydrogen peroxide because of the imbalance in the ratio of SOD-1 to CAT and GPX. Hence, this will lead to the increase of neuronal cell death which also c ontributes to the progressive mental decline in both Down syndrome and Alzheimer disease. In peripheral tissues, SOD-1 has 50% more in patients than normal in the immune system. Hence, it will disrupt the immune system to make the patients to be weaker (Benzi et al, 1997). The E2F-1 Gene The E2F-1 gene is located in human chromosome 20. It encodes a protein E2F-1 transcriptional factor E2F-1. This transcription factor plays major role in in the control of cell cycle, action of tumor suppressor proteins and DNA damage to apoptosis. The ETS2 Gene The ETS2 gene is located on human chromosome 21q22.2. This gene encodes for a protein Protein C-ets-2 which is a transcriptional factor of beta-APP gene. It will specifically bind to the beta-APP promoter and work with transcription factor AP1 (Wolvetang et al, 2003). The Oestrogen Hormone Oestrogen has a role of protecting neurons from the toxic effect by amyloid-beta , ameliorated the cerebral metabolism and also increase the level of acetylcholine in the basal forebrain and hippocampus. It also has the antioxidant effect which is very helpful towards Alzheimer disease. Other beneficial impacts include reduction of the lipid peroxidation, prevention intracellular peroxide accumulation and reduce the degradation of the neurons in the brain. So, it is said that estrogens reduce the occurrence of Alzheimer disease of Down syndrome woman. Woman patients with Down syndrome may have an earlier occurrence or more serve form of Alzheimer disease when these women has early onset of menopause compared to those late menopause women (Schupf et al., 2006). But those post-menopause women that receive estrogen replacement therapy may have a lower occurrence in having Alzheimer disease. The Apolopoprotein E Gene Another factor that attribute to the late onset of Alzheimer disease is Apolopoprotein E (APOE) gene. This gene is located on chromosome 19 and has 3 types of alleles (Corder et al., 1993). The allele that is responsible for Alzheimer disease is APOE ÃŽÂ µ4 allele. It is found that patients with Alzheimer disease has higher frequencies of the APOE ÃŽÂ µ4 allele compared with those without other APOE genotypes and have a earlier onset of Alzheimer disease (Corder et al., 1993). Another allele that has good contribution towards Alzheimers disease for adults with Down syndrome is APOE ÃŽÂ µ2. It is the least common allele but can reduce the risk of Alzheimers disease for adults with Down syndrome (Schupf et al,1996). Cholesterol is transported by high-density lipoproteins such as APOE, and these suggested of the hypothesis that the relationship between APOE and risk of Alzheimers disease may be linked to cholesterol metabolism. Statins or HMG-CoA reductase inhibitors are currently the most widely prescribed class of cholesterol lowering medication. In a number of studies, it has been shown that the use of statin does reduced the risk of the Alzheimers disease. So, for participants with a total cholesterol level of 200 mg/dL or more, the effect of statin significantly lower the risk of dementia compared to that of other participants with lower total cholesterol (Green, Jayakumar, Benke, Farrer, 2002). The Sortilin-related receptor-1 Gene On chromosome 11 (11q24.1), there is this gene called sortilin-related receptor-1 gene (SORL1). It is a 250-kDa membrane protein that is expressed in the neurons of the nervous system. The SORL1 gene has the role of intracellular trafficking between membrane and hence, interacting with amyloid precursor protein (APP) in endosomes and golgi. This gene function to get rid the excess beta amyloid protein. So, when there is little expression of this gene, it will cause to the increase of beta amyloid protein hence it will lead to the accumulation of beta amyloid protein. Since there is already a large amount of beta amyloid protein in the brains of the Down syndrome patients, then it will have problem to decrease the amount of beta amyloid protein so it will increase the risk of having Alzheimer disease. (Rogaeva et al, 2007) The Phorsphorylation Phosphorylation is a mechanism that controls the activity of enzymes and receptors by switching on the regulation of the cell function. Constant activation of the phosphorylation mechanism will increase the accumulation of the of neurofibrillary tangles, abnormal twisted protein filaments that form within affected neurons and are composed mainly of hyperphosphorylated tau protein (Hardy et al, 1991). So, the hyperphosphorylated tau protein in the brain of the transgenic mice with extra human minbrain-kinase gene also give us the indication of the overexpression of minibrain-kinase could contribute to the early onset of Alzheimers disease associated with Down syndrome ( Wegiel et al, 2008). The Age There have been studies that suggest that overall dementia risk increases beginning in the late 40s or early 50s and even some twenty years earlier than it does within the general population. However, there is still some individuals vary on the onset age. A small minority of adults with Down syndrome begin to experience substantial declines in cognition before age 50, yet another minority is able to mature well into their late 60s or early 70s without experiencing signs or symptoms of Alzheimers disease (Schupf, 2002). There are studies on the different ages of mothers who give birth to their children to have risk of having dementia. The results showed a four-fold increase in risk of dementia among mothers who gave birth to their children with Down syndrome less than 35 years of age compared with mothers who were older than 35 years when their child with Down syndrome was born or compared with mothers of children with other intellectual disabilities (Schupf et al., 1994). The Biomarkers Biomarkers are used to monitor diseases progression so it is very useful in quantifying the effects of any available treatment regimen. Because biomarkers are strongly associated with disease risk, detection of early changes in biomarker levels provides an opportunity for early intervention to delay or prevent disease onset (Lesko Atkinson, 2001). To date, validated biomarkers for Alzheimers disease in adults with Down syndrome have yet to be discovered. However, there are some biomarkers that have been investigated. These include measures of the quantity and type of beta amyloid protein found in blood plasma and telomere size in metaphase and interphase preparations as well as on individual chromosomes (Schupf, Patel et al., 2001). There is a close relationship between Down syndrome and Alzheimer disease mainly cause by the overexpression of the APP gene and lead to the over production of the protein, amyloid-beta protein(1-40/42), the major contribution to Alzheimer disease pathogenesis in Down syndrome patient. It is reported in both cross-sectional and prospective analyses that beta-amyloid 1-42 levels increased in demented adults with Down syndrome but not beta amyloid 1-40 levels. For people who are nondemented but with high plasma beta-amyloid 1-42 levels were over two times as likely to develop Alzheimers disease as those with lower levels (Schupf, Patel et al., 2001). Telomeres are DNA sequences that located at the end of the chromosome which is a series of repeats of the TTAGGG nucleotide sequence. These DNA sequences undergo shortening with each cell division, serving as markers of a cells replicative history and an indicator of cellular aging. Using quantitative telomere protein nucleic acid fluorescent in situ hybridization (FISH) analyses of metaphase and interphase preparations from age matched pairs of participants with Down syndrome with and without dementia, there are four observations being observed. The first observation is there are shorter telomeres in individuals with dementia. Next, the individual chromosomes 1 and 21 could be used alone and/or in combination to detect telomere shortening. The third observation is that the cells from individuals with dementia or MCI had reduced numbers of telomere signals when analyzed using a PNA telomere probe, and lastly the shorter telomeres in individuals with MCI (Jenkins, Velinov, Ye, Gu, Li et al., 2006). The Conclusion In conclusion, Down syndrome showed that it has a relationship with the pathology of Alzheimer disease. Triplication of chromosome 21that causes over expression of the amyloid-beta protein is the major cause towards the pathology of Alzheimer disease. Not only so, some other sub factors also contribute to it. After understanding the various causes that resulted in Down syndrome patients to have Alzheimer disease, it will be easier for us to invent more ways to treat all these symptoms and hence it will definitely benefit a lot of people that are associated with these diseases.

Fireworks :: essays research papers

Every year, America celebrates many holidays with fireworks. One of the most popular selections is a Roman Candle. If you want to try to make this at home, common pyrotechnics stores have all the supplies you would need. Just think of the â€Å"oohhs† and â€Å"ahhhhs† when you light off your homemade fireworks at home.   Ã‚  Ã‚  Ã‚  Ã‚  First of all, you need a sturdy, good tube. The tube should be cylindrical and should be at least 3/32 of an inch thick. The opening at the top of your tube should have a 5/8 inch opening. Then take a 1/16 inch fuse, make sure it covers the whole tube and sticks out a little bit, just like any other firework and keep the tube in place by using tape. Next, 1.25 grams of 3F BP should be poured into the tube. Then, gently put a one-half inch star down the tube. This is what will go up into the air and is responsible for the shots. Then, put some sawdust through the tube. Make sure the sawdust is evenly spread and turn the tube over. All contents should not fall out if this is done correctly. Make sure you use some sort of mechanism to push down upon the sawdust. Keep repeating these instructions. The tube should consist of bp, star, sawdust, bp, star, and sawdust for as many shots as you want. Good Luck with your newly made Roman Candle and have a safe experience. Next, we will examine how to make a salute go up in the air. Salutes are generally products that make a Kaboom sound when launched.   Ã‚  Ã‚  Ã‚  Ã‚   The lifting cup is made when you glue kraft paper that overhangs the salute. Next, you add some lift usually gunpowder to propel it. The inner paper should be glued with a small device or a glue gun. Meanwhile, while the glue is wet fold the paper into quarters. Place a cut in the newly formed pouch and add a piece of quick match. Now, we will learn how to make salute inserts. First off, buy some top- notch 3 inch tubes. Take all of your tubes and set them on a piece of tin foil. Secondly, you need to fill a tube to the top with hot glue and as the glue is about to dry put it into the freezer for 5 minutes. After 5 minutes is up pull the tin foil off of the tubes and put toilet paper down the open end of the tube.

Disease Control and Prevention

There are three basic approaches to preventing and controlling transmission of diseases: a) vector control (if applicable), b) personal protection, and c) vaccination (â€Å"How Vaccines Prevent Disease†). The CDC has expanded existing domestic and international community-based control programs for preventing infectious diseases. New preventive projects are being evaluated, including preventives of antimicrobial resistance, food borne and water borne illness and others.â€Å"Prevention is better than cure† – we always hear this statement whenever a new disease outbreak occurs to a community or a region. Disease prevention is indeed far more economical than treating the disease itself. One of the most practiced is the use of vaccines (Overturft). Prevention and control of all non-vaccine preventable diseases must rely on vector control and personal protection. Vector control however is seldom supported as a n independent program.Rather, it is in general incorporat ed into a larger prevention program that engages active surveillance for the disease and the vectors, personal protection, diagnosis and management of the disease and vector control. The purpose of surveillance is to help prevent disease by providing a mechanism for early caution or epidemic action, thus allowing for public health action. This is more than ever true for vector borne diseases such as dengue that often cycle silently in an area with intermittent epidemics that may cause significant morbidity and mortality.As a result, it is significant to have active laboratory based surveillance for infectious diseases to keep an eye on transmission even though there may be no evident disease in humans or domestic animals (Gersovitz and Hammer). To manage the condition, and the global nature of the diseases, the World Health Organization has responded by expanding its surveillance and other operations to meet the challenge of emerging and recurrent infectious diseases (â€Å"Infecti ous Diseases†). Disease Control and Prevention In a family which has a history of birth defect cases, it is difficult to accept the truth that your future child has a greater risk of having a birth defect. Prevention of the possible birth defects is the most common advice given to the family by many doctors. The proper and enough absorption of folic acid give many expectant mothers low risk of having babies with birth defects. Not all birth defects are fatal or untreatable like many parents believe. Many improved medications on birth defects are available and guaranteed to prevent having babies with birth defect.Some are treatment for babies that still in the womb. The most important thing for the treatment is to be able for the mother to understand the risk factors and how she can prevent having a baby with a birth defect. Knowledge about Birth Defects A birth defect is an abnormality of structure, function or metabolism that is present at birth. This abnormality leads to mental or physical disability or can lead to death. Many birth defects are known ranging from minor to serious. They are considered the leading cause of death of many babies in their first year of life.According to the Center for Disease Control and Prevention (CDC), about 120,000 babies are born each year suffering from birth defects in the United States alone. Causes of Birth defects About 60% of the birth defect cases have unknown causes. Environmental and genetic factors are also causes of birth defects (Morbidity and Mortality Weekly Report, 352-356). Genetically inherited birth defects occur when one or both parents pass along a defective gene to the child. Genes carry thread-like structures called chromosomes that determine individual characteristics and feature (Millensky, 1989, 201-267).Any faulty or missing gene can cause birth defect. Some of the birth defects can only occur if both parents are carrier of the defect. Even healthy parents can have effective genes and pass this on to their child. This kind of event is called the recessive inheritance. Recessive diseases are more severe than dominant diseases. Some examples of birth defects that are caused by recessive inheritance are sickle cell anemia, Tay-Sachs disease, phenylketonuria (PKU) and cystic fibrosis (Millensky, 1989, 201-267).If only one parent passes along the recessive gene, the normal gene received from the other parent will prevent the disease. However, that child will be a carrier of the disease. The carrier of the disease has a 25% chance to have the disease if the other parent is also a carrier. Birth defects, such as Down syndrome, can also be caused by too many chromosomes or damaged chromosomes. Babies with Down syndrome have varying level of mental retardation and heart defects.On the other hand, environmental causes of birth defects include poor prenatal care, exposure to chemicals or radiation and use of drugs and alcoholic drinks during pregnancy. Any substance that can cause any abnormal development is termed â€Å"teratogenâ⠂¬â„¢ (Benneth, 2006, 217-230). Certain infections can result in birth defects when the woman deals with it during her pregnancy. About 40,000 babies a year are born with a viral infection known as cytomegalovirus (CMV) (Morbidity and Mortality Weekly Report, 352-356). These babies develop serious disabilities including mental retardation and loss of vision and hearing.Some of the other infections that can cause birth defects include syphilis, toxoplasmosis, Venezuelan equine encephalitis and parvovirus (Benneth, 2006, 217-230). In unusual cases, having a chicken pox during pregnancy can also cause birth defect. Much absorption of alcohol during pregnancy can cause fetal alcohol syndrome. This syndrome includes mental retardation, low birth weight and heart problems. If alcohol has severe cause, so is the improper use of drugs. Drugs that can cause birth defects include tetracycline, sulfa drugs, hormone supplements and recreational drugs such as cocaine and LSD.Some birth defects, such as neural tube defects and cleft lip and palate are considered multifactorial birth defects which are caused by a combination of environmental and genetic factors. Other causes of birth defects are Rh disease. This disease is the incompatibility of the mother’s and baby’s positive and negative blood factors (3). Common Birth Defects The most common defects in the United States are the Cleft lip or palate and Down syndrome. Each year, about 6,800 and 5,500 babies are born with cleft lip/ palate and Down syndrome respectively (Morbidity and Mortality Weekly Report, 352-356).Effects of cleft lip/ palate include problems in eating, speech and language. Cleft lip/ palate are not dangerous and surgical repair of the cleft can be done when the child reach the right age and size and is in good health to tolerate surgery. The most common problem encountered by children with clefts is hear infections. The cleft allows fluid and germs to enter the ears more easily that norma l that causes the infections in the ear. The occurrence of cleft lip/ palate can also cause more cavities leading to dental problems, thus, dental checkup is recommended by doctors.Moreover, statistics show that about 1,900 babies are born with a serious heart defect called transposition of the great arteries each year (Morbidity and Mortality Weekly Report, 352-356). Though advances in surgery developed the outlook for affected babies, heart defects still remain as the leading cause of birth defect infant deaths (Martin, 619-622). Doctors and many experts can not explain the real causes of abnormality in the heart, although both genetic and environmental factors are considered.Another defect that is caused by both genetic and environmental factors (including insufficient amount of folic acid) is the Spina Bifida or open spine. According to the Center for Disease Control and Prevention (CDC), about 1,300 cases occur each year. Other common birth defects include musculoskeletal defec t (arm and leg defect), gastrointestinal defects, and eye defects (). Martin, 619-622 Birth Defect of Body Chemistry Birth defects of body chemistry are not visible, but they can be harmful and worst, fatal. In 2002, about 3,000 babies were born with defects affecting body chemistry.A recessive genetic disease is the common cause of disorder of body chemistry. The inability of cells to produce enzymes or proteins that are needed to carry substance from one place to another to change certain chemicals to another is the main cause of this disease. An example is Tay – Sachs disease. Affected babies lack an enzyme needed to break down certain fatty substances in the brain cells. These fatty substances destroy brain cells that may result to blindness, paralysis and even death at the age of 5. Another example is phenylketonuria (PKU).In this disease, the baby cannot process a part of protein which builds up and damage the brain. Birth Defect Testing There are two types of testing a vailable in many hospitals and health centers to look for possible occurrence of birth defects. The first one is the screening test, which is able to look whether the baby is likely to have birth defects. If the screen test is positive, the second teat which is the diagnostic test should be performed. The rule of the diagnostic test is to confirm or rule out the possible problem that was detected by the screen test.Screening tests The processes involve in performing screen test that looks for Down syndrome are the nuchal fold ultrasound and a blood test. The ultrasound test uses sound waves to measure the thickness of the fetus’ neck while the blood test is intended to measure the levels of beta-hCG and a protein called pregnancy- associated plasma protein. Another screening test that is done between 15-20 weeks of pregnancy is the maternal serum triple or quadruple screening test. These tests check the amounts of three or four substances in a pregnant woman’s blood.Es timation of the chance of the fetus to have Down syndrome or other health problems is done after these blood tests. The quad screen on the other hand, check the substances (alpha-fetoprotein, and unconjugated estriol) and the level of hormone inhibin A. The doctors estimate the tendency of a woman to have a child with birth defects or other health problems through the data provided by the tests along with the age of the woman and other certain factors. Ultrasound on the other hand is a test that shows the development of the baby.This is usually done during the 18th and 20th week of pregnancy. Ultrasound can be used to screen some chromosomes with problems and find structural problems of the heart, spine, abdomen and other parts of the body. Diagnostic test Doctors usually used Chorionic villus sampling (CVS) to look at cells in the placenta. In this test, a sample of chorionic villus cells is collected by putting a small tool into the uterus through the vagina or by putting a needle through the belly into the uterus. This test can find many family diseases such as hemophilia and sickle cell disease.Another test under diagnostic is Amniocentesis which looks for many chromosomal problems by looking at the cells in the amniotic fluid. This test can find neural tube defects such as Spina bifida. Newly- born babies can also be tested, with the permission of the parents, for possible birth defects. Usually, all states perform PKU and congenital hypothyroidism on all the babies. The tandem mass spectroscopy is a new technique used by many state to newborn babies. This technique provides many features that screens for many disorders of metabolism on a small blood sample. PreventionThere are many ways of reducing the risk of a woman having a baby with birth defect. These ways should be remember and should be take into consideration by many women who wants to have a healthy with no physical or mental defects. One important thing to remember is the preconception visit wi th the health care provider. The health provider identifies the health conditions, such as high blood pressure and diabetes, which may cause risk in pregnancy. The provider can advice on lifestyle factors, such as quitting smoking and alcohol drinking that can cause risk in pregnancy.The medication intake of the woman is also check by the health provider to make sure that the medication is safe to pregnancy. The visit to health providers is crucial to women with chronic health problems, such as diabetes and high blood pressure. A great example is the woman which have diabetes has more likely to have a baby with birth defect compare to the woman who is not diabetic. Controlling the blood sugar levels of the woman starting before pregnancy can give low risk of having a baby with serious birth defects (11). This advice can be provided by the health care providers.Another thing that can be done by the health provider during the preconception visit is to see whether the vaccinations of t he woman are up to date. If the woman has no vaccines against chickenpox and rubella, she has to be vaccinated before pregnancy. In this way, possible risk of birth defect can be lower against woman with no vaccines. Vaccinated woman should wait for a month after being vaccinated before trying to become pregnant. All women should also know their health history including that of their partner and their family. With this, the provider can identify risk factors for inherited genetic conditions.The usual thing that the provider does when this case occurs is to refer the couples to genetic counselor that can explain the risk of birth defects and provide them assistance in conducting proper tests. Pregnant woman or woman who is planning to get pregnant should avoid any alcohol absorption, smoking and intake of drugs. The woman should not take any medication over the counter without making sure that this medication is safe for pregnant women. All women who could become pregnant should take a daily multivitamins containing folic acid.Studies show that proper intake of folic acid during early pregnancy will provide low risk of having a baby with neural tube defects (Spina bifida). Folic Acid to Prevent Birth Defects Folic acid is a synthetic form of folate which is a b vitamin found in a variety of foods. Folate is needed both before and in the first weeks of pregnancy and can help reduce the risk of having babies with common birth defects such as neural tube defects, which affect the brain and spinal cord. Neural tube defects can occur in an embryo before a woman realizes she is pregnant.This is the reason why it is important for all women age 15 to 45 to include folate in their balanced diet. With this, women who will get pregnant reduce their risk of having a baby with defect of the brain or spinal cord. New technologies were developed to include folate in many food supplements. The Food and Drug Administration requires food manufacturers to fortify enriched grain p roducts with folic acid. In this way, women can get sufficient amount of folic acid even in breads and fortified grains such as enriched pasta, rice, waffles and cereal bars. Other ways for pregnant women to have sufficient amount of folic acid are as follows:1) Eat fruits, dark-green leafy vegetables, dried beans and peas, and other foods that are natural sources of folate, 2) Eat folic acid-fortified enriched cereal grain products and breakfast cereals, 3) Take a food supplement containing folic acid. Nutrition information indicated on the labels of many food and dietary supplements can guide many women in identifying the amount of folic acid they are obtaining. Neural Tube Birth Defects The technical names of the two major neural tube birth defects reduced by adequate folate intake are anencephaly and Spina bifida.With proper medical treatment, most babies born with Spina bifida can survive to adulthood. But they may require leg braces, crutches, and other devices to help them wa lk. Other maternal factors also may contribute to the development of neural tube defects. Among these include the following: 1) use of certain ant seizure medications, 2) severe overweight, 3) family history of neural tube defects, 4) prior neural tube defect-affected pregnancy, 5) fever during early pregnancy and 6) diabetes. Studies about Folate In the 1950’s, scientist first suggested a connection between neural tube birth defects and diet.This incidence has always been higher in low socioeconomic groups in which women may have poorer diets. Another study looked at folic acid intake in Hungarian women. The evidence indicated that mothers who had never given birth to babies with neural tube defects and who took a multivitamin and mineral supplement with folic acid had less risk in subsequent pregnancies for having babies with neural tube defects than women given a placebo. Another study conducted by the U. S. Public health service in September 1992 resulted to a data that s hows that all women of childbearing age capable of becoming pregnant consume 0.4 mg of folate daily to reduce the risk of having a pregnancy with Spina bifida. This value corresponds to FDA’s Daily Value for folic acid, which is 400 micrograms for non-pregnant women. On the other hand, the Department of Agriculture said that many women between 19 and 50 consume much less than 400 micrograms of folate a day. Where to obtain Folic Acid Folate occurs naturally in a variety of foods, including liver, dark-green leafy vegetables such as collards, turnip greens, and Romaine lettuce, broccoli and asparagus, citrus fruits and juices.Folate can also be obtained from dietary supplements, such as folic acid tablets and multivitamins with folic acid, and from fortified breakfast cereals. Certain information on food and dietary supplement labels can help women spot foods containing substantial amounts of folate. The exact amount of folic acid is indicated in the label’s nutrition f acts panel. Some food and dietary supplement labels may claim that their product has sufficient amount of folic acid that reduce risk of having babies with birth defects. The products that claim this must: 1) provide 10 percent or more of the daily value for folic acid per serving;2) not contain more than 100 percent of the daily value for vitamins A and D per serving because high intakes of these vitamins are associated with other birth defects; and 3) List on the label’s Nutrition or Supplement facts panel the amount by weight in micrograms. This claim about folate is supported by the studies and statistics have been discussed but these alone will not ensure a healthy baby with no birth defects. Not only folate intake, but genetics is one of the factor that affect the pregnancy and providing risk to have babies with defects. Women have options for reaching the folate intake goal.They can attain this both before and during pregnancy by having a healthy balanced diet. The com bination of having proper intake of folic acid will ensure that women have low risk of having babies with birth defects. References American Academy of Pediatrics. Cytomegalovirus, in Pickering, L. K. (ed. ), Red Book: 2003 Report of the Committee on Infectious Diseases, 26th edition. Elk Grove Village, IL: American Academy of Pediatrics, 259-262. Benneth, K. A. Fetal Surgery for Myelomeningocele, In Wyszynski. Neural Tube Defects from Origin to Treatment. New York City, Oxford University Press, 2006, 217-230.Birth Defects. Retrieved May 18, 2008, from Center for Disease Control and Prevention (CDC). Spina bifida and Anencephaly Before and after Folic Acid Mandate, 1995-1996. Morbidity and Mortality Weekly Report, volume 53, number 17, 362-365. Children , Youth and Women’s Health Service. Alcohol- Effects on Unborn Children. Retrieved May 20, 2008, from Department of Human Service. Birth Defects in Victoria in 2003 and 2004. Retrieved May 18, 2008, from http://www.betterhea lth. vic. gov. au/bhcv2/bhcarticles. nsf/pages/Birth_defects_in_Victoria_2003_to_2004 Department of Health and Human Services, Center for Diseases Control and Prevention. Fetal Alcohol Spectrum Diseases. Retrieved May 20, 2008, from http://www. cdc. gov/ncbddd/fas/fasask. htm Martin, J. A. , et al. Annual Summary of Vital Statistic. Pediatrics, Volime115, number 3, 619-634. Millensky, Aubrey. (1989). Genetic Disorders and the Fetus. 3rd edition, 201-267. New York: Plenum Press. (1995)Tropical Pediatrics and Environmental Child Health, Vol. 23, number 1, 4-10.

Master’s Prepared Interview Essay

The Master of Science in Nursing with an emphasis in nursing education can be understood in further detail by an interview process outlining a person’s career overview, graduate educational experience and their present vocational position. The individual chosen (D.C.) is a mentor, who is handing down the baton to me, as the clinical instructor for a group of nursing students at Biola University. D.C. has numerous years experience as a bedside nurse as well as an educator. Overview of Career D.C. always knew she wanted to be a nurse and began nursing school at the young age of 17. In 1977, she received her Advanced Degree in Nursing (ADN) from Umpqua Community College in Roseburg. She went on to receive her Bachelor’s Degree in Management from Georgefox University, in Newburg, Oregon. The positions she held included: working as a bedside nurse for three years, a nurse in critical care for seven years and a supervisor/manager for 20 years. This 30-year experience took place at a community hospital called Providence Health and Services, in Oregon. Graduate Education D.C. went on to receiver her Master’s in Leadership and Nursing Education from Warner Pacific University in Portland, Oregon, from 2006-2008. While attending graduate school she continued to work at Providence Health and Services. Her current position made it necessary to go back to school because the institution was requiring all supervisors to have a Master’s degree. D.C. enjoyed her on-line educational experience from Warner Pacific. After her degree, she became the manager/director for  multi-services including: wound care, care management, social  services, medical-surgical and telemetry units. This took place over a four-year period and then D.C. became the Director of Education at Providence for an additional three years. This is where she taught for the University of Great Falls, Montana for their RN to BSN satellite program. D.C. taught live, virtual classrooms with students from many states. She retired from Providence in 2011 and moved to California with her beloved husband, who became the Dean of Rosemead, at Biola University, in La Mirada, California. Present Position Soon after her move to California, D.C. was asked by the nursing department of Biola University, if she would consider teaching for them. She said no at first but then was enticed to begin as a part time clinical instructor for the Bachelor’s in Nursing Program. She began as a community health instructor and then applied for the full-time position as an Associate Professor. She taught Management and Leadership in the fall and Nursing Community in the spring. D.C. is a Level Coordinator for all level 3 activities in the nursing department and part of the administration team as well. Competencies learned in the graduate program included team building, coaching, developing unity and administration skills. Some of her various certifications over the years include: Medical/Surgical Certified, ACLS, PALS and NRP. She also is a master trainer for crucial conversations and a senior facilitator for select interview training. While at Biola University, D.C. also took 80 hours of epidemi ology online through the Center’s for Disease Control. She is also part of the FEMA disaster response program and held an earthquake preparedness day at the university this year. Her graduate degree gave her all the necessary tools to confidently teach at a university level. Pearls of Wisdom For any student in a graduate program it is essential to have a mentor who can give you advice. Words of wisdom from D.C. included â€Å"Everything is a conversation. Even if the conversation is  painful, be open and honest.† The next golden nugget from D.C. was, â€Å"Just do what’s next and pretty soon you’re done.† This helped me to realize to take one step or one assignment at a time and not look with fear to the future. D.C learned organizational skills and was able to write specific objectives for nursing education. Her thesis was on how to be a new graduate with confidence and competence. She learned a new appreciation for people cultural diversity. One thing she learned the most about herself was that she was biased. She encouraged me to question my biases and assumptions in everything we do. These were some incredible tools I will take with me as I continue through the graduate program. Conclusion The effects of graduate education can enhance your skills, increase your knowledge, give you more awareness culturally, enable you to have better organization and make decisions, as well as become a better communicator. D.C. felt she was able to practice her new skills at the hospital she was already working for in a safe environment with people she trusted. What was affected the most in D.C.’s experience during grad school was her attitude. She gained a broader perspective and realized there was so much to gain from others. She felt her graduate degree gave her critical thinking skills that she can use forever. D.C. was an excellent example of someone who has used their graduate degree to the fullest extent as teacher, mentor, advisor and facilitator. The Master of Science in Nursing can be understood in further detail by an interview process outlining a person’s career overview, graduate experience and their present career. I have gained a clearer understanding of the benefits of a graduate degree and am excited to be on this journey with fellow nurse enthusiasts.

10 Facts About Chromosomes

10 Facts About Chromosomes Chromosomes are cell components that are composed of DNA and located within the nucleus of our cells. The DNA of a chromosome is so long, that it must be wrapped around proteins called histones and coiled into loops of chromatin in order for them to be able to fit within our cells. The DNA comprising chromosomes consists of thousands of genes that determine everything about an individual. This includes sex determination and inherited traits such as eye color, dimples, and freckles. Discover ten interesting facts about chromosomes. 1) Bacteria Have Circular Chromosomes Unlike the thread-like linear strands of chromosomes found in eukaryotic cells, chromosomes in prokaryotic cells, such as bacteria, typically consist of a single circular chromosome. Since prokaryotic cells do not have a nucleus, this circular chromosome is found in the cell cytoplasm. 2) Chromosome Numbers Vary Among Organisms Organisms have a set number of chromosomes per cell. That number varies across different species and is on average between 10 to 50 total chromosomes per cell. Diploid human cells have a total of 46 chromosomes (44 autosomes, 2 sex chromosomes). A cat has 38, lily 24, gorilla 48, cheetah 38, starfish 36, king crab 208, shrimp 254, mosquito 6, turkey 82, frog 26, and E.coli bacterium 1. In orchids, chromosome numbers vary from 10 to 250 across species. The adders-tongue fern (Ophioglossum reticulatum) has the most number of total chromosomes with 1,260. 3) Chromosomes Determine Whether You are Male or Female Male gametes or sperm cells in humans and other mammals contain one of two types of sex chromosomes: X or Y. Female gametes or eggs, however, contain only the X sex chromosome, so if a sperm cell containing an X chromosome fertilizes, the resulting zygote will be XX, or female. Alternatively, if the sperm cell contains a Y chromosome, than the resulting zygote will be XY, or male. 4) X Chromosomes Are Bigger Than Y Chromosomes Y chromosomes are about one-third the size of X chromosomes. The X chromosome represents about 5% of the total DNA in cells, while the Y chromosome represents about 2% of a cells total DNA. 5) Not All Organisms Have Sex Chromosomes Did you know that not all organisms have sex chromosomes? Organisms such as wasps, bees, and ants do not have sex chromosomes. Sex is therefore determined by fertilization. If an egg becomes fertilized, it will develop into a male. Unfertilized eggs develop into females. This type of asexual reproduction is a form of parthenogenesis. 6) Human Chromosomes Contain Viral DNA Did you know that about 8% of your DNA comes from a virus? According to researchers, this percentage of DNA is derived from viruses known as Borna viruses. These viruses infect the neurons of humans, birds and other mammals, leading to infection of the brain. Borna virus reproduction occurs in the nucleus of infected cells. Viral genes that are replicated in infected cells can become integrated into chromosomes of sex cells. When this occurs, the viral DNA is passed from parent to offspring. It is thought that Borna virus could be responsible for certain psychiatric and neurological illness in humans. 7) Chromosome Telomeres are Linked to Aging and Cancer Telomeres are areas of DNA located at the ends of chromosomes. They are protective caps that stabilize DNA during cell replication. Over time, telomeres wear down and become shortened. When they become too short, the cell can no longer divide. Telomere shortening is linked to the aging process as it can trigger apoptosis or programmed cell death. Telomere shortening is also associated with cancer cell development. 8) Cells Dont Repair Chromosome Damage During Mitosis Cells shut off DNA repair processes during cell division. This is because a dividing cell does not recognize the difference between damaged DNA stands and telomeres. Repairing DNA during mitosis could cause telomere fusion, which may result in cell death or chromosome abnormalities. 9) Males Have Increased X Chromosome Activity Because males have a single X chromosome, it is necessary for cells at times to increase gene activity on the X chromosome. The protein complex MSL helps to up-regulate or increase gene expression on the X chromosome by helping the enzyme RNA polymerase II to transcribe DNA and express more of the X chromosome genes. With the help of the MSL complex, RNA polymerase II is able to travel further along the DNA strand during transcription, thereby causing more genes to be expressed. 10) There Are Two Main Types of Chromosome Mutations Chromosome mutations sometimes occur and can be categorized into two main types: mutations that cause structural changes and mutations that cause changes in chromosome numbers. Chromosome breakage and duplications can cause several types of chromosome structural changes including gene deletions (loss of genes), gene duplications (extra genes), and gene inversions (broken chromosome segment is reversed and inserted back into the chromosome). Mutations can also cause an individual to have an abnormal number of chromosomes. This type of mutation occurs during meiosis and causes cells to have either too many or not enough chromosomes. Down syndrome or Trisomy 21 results from the presence of an additional chromosome on autosomal chromosome 21. Sources: Chromosome. UXL Encyclopedia of Science. 2002. Encyclopedia.com. 16 Dec. 2015.Chromosome Numbers For Living Organisms. Alchemipedia. Accessed 16 Dec. 2015.X chromosome Genetics Home Reference. Reviewed January 2012. Y chromosome Genetics Home Reference. Reviewed January 2010.

Free Essays on Enterprise Computing

Enterprise Computing (ERP Systems) Table of Contents Enterprise Resource Planning – An Overview . . . 3 ERP Vendor Selection . . . . . . . . . . . . . . . . . . . . . . 6 ERP Providers and Products . . . . . . . . . . . . . . . . 11 Pros and Cons of ERP Systems . . . . . . . . . . . . . . 14 Companies With ERP Systems . . . . . . . . . . . . . . 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Enterprise Resource Planning – An Overview Enterprise Resource Planning systems are a new type of business management computing systems that integrate all the facets of a business including planning, marketing, sales, and manufacturing. ERP systems were originally used to serve the information need of manufacturing companies. Over time they have grown to serve many other industries such as health care, financial services, and the consumer goods sector. The first ERP systems ran on mainframe computers. They then migrated to the more popular client/server systems and today they are moving towards a web based network system that includes numerous applications. These web-based ERP systems help automate a company’s business process by employing an integrated user interface, and integrated data set, and an integrated code set. Today, ERP systems software lies at the heart of any large enterprise’s computing activity. ERP software integrates all the information used by an organization’s many different departments and other cross functional groups into a unified computing system. This software enables everyone within the company to access information from the same database. Information such as employee records, customer data, purchase orders, and inventory can all be stored and accessed within the same network. ERP systems are being positioned as the foundation of enterprise wide information systems. Such systems will link together all of a company’s operations as well as c... Free Essays on Enterprise Computing Free Essays on Enterprise Computing Enterprise Computing (ERP Systems) Table of Contents Enterprise Resource Planning – An Overview . . . 3 ERP Vendor Selection . . . . . . . . . . . . . . . . . . . . . . 6 ERP Providers and Products . . . . . . . . . . . . . . . . 11 Pros and Cons of ERP Systems . . . . . . . . . . . . . . 14 Companies With ERP Systems . . . . . . . . . . . . . . 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Enterprise Resource Planning – An Overview Enterprise Resource Planning systems are a new type of business management computing systems that integrate all the facets of a business including planning, marketing, sales, and manufacturing. ERP systems were originally used to serve the information need of manufacturing companies. Over time they have grown to serve many other industries such as health care, financial services, and the consumer goods sector. The first ERP systems ran on mainframe computers. They then migrated to the more popular client/server systems and today they are moving towards a web based network system that includes numerous applications. These web-based ERP systems help automate a company’s business process by employing an integrated user interface, and integrated data set, and an integrated code set. Today, ERP systems software lies at the heart of any large enterprise’s computing activity. ERP software integrates all the information used by an organization’s many different departments and other cross functional groups into a unified computing system. This software enables everyone within the company to access information from the same database. Information such as employee records, customer data, purchase orders, and inventory can all be stored and accessed within the same network. ERP systems are being positioned as the foundation of enterprise wide information systems. Such systems will link together all of a company’s operations as well as c...

Causes of World War I and the Rise of Germany

Causes of World War I and the Rise of Germany The early years of the 20th century saw tremendous growth in Europe of both population and prosperity. With arts and culture flourishing, few believed a general war possible due to the peaceful cooperation required to maintain increased levels of trade as well as technologies such as the telegraph and railroad. Despite this, numerous social, military, and nationalistic tensions ran beneath the surface. As the great European empires struggled to expand their territory, they were confronted with increasing social unrest at home as new political forces began to emerge. Rise of Germany Prior to 1870, Germany consisted of several small kingdoms, duchies, and principalities rather than one unified nation. During the 1860s, the Kingdom of Prussia, led by King Wilhelm I and his prime minister, Otto von Bismarck, initiated a series of conflicts designed to unite the German states under their influence. Following the victory over the Danes in the 1864 Second Schleswig War, Bismarck turned to eliminating Austrian influence over the southern German states. Provoking war in 1866, the well-trained Prussian military quickly and decisively defeated their larger neighbors. Forming the North German Confederation after the victory, Bismarcks new polity included Prussias German allies, while those states which had fought with Austria were pulled into its sphere of influence. In 1870, the Confederation entered into a conflict with France after Bismarck attempted to place a German prince on the Spanish throne. The resulting Franco-Prussian War saw the Germans rout the French, capture Emperor Napoleon III, and occupy Paris. Proclaiming the German Empire at Versailles in early 1871, Wilhelm and Bismarck effectively united the country. In the resulting Treaty of Frankfurt which ended the war, France was forced to cede Alsace and Lorraine to Germany. The loss of this territory badly stung the French and was a motivating factor in 1914. Building a Tangled Web With Germany united, Bismarck began setting about to protect his newly formed empire from foreign attack. Aware that Germanys position in central Europe made it vulnerable, he began seeking alliances to ensure that its enemies remained isolated and that a two-front war could be avoided. The first of these was a mutual protection pact with Austria-Hungary and Russia known as the Three Emperors League. This collapsed in 1878 and was replaced by the Dual Alliance with Austria-Hungary which called for mutual support if either was attacked by Russia. In 1881, the two nations entered into the Triple Alliance with Italy which bound the signatories to aid each other in the case of war with France. The Italians soon undercut this treaty by concluding a secret agreement with France stating that they would provide aid if Germany invaded. Still concerned with Russia, Bismarck concluded the Reinsurance Treaty in 1887, in which both countries agreed to remain neutral if attacked by a third. In 1888, Kaiser Wilhelm I died and was succeeded by his son Wilhelm II. Rasher than his father, Wilhelm quickly tired of Bismarcks control and dismissed him in 1890. As a result, the carefully built web of treaties which Bismarck had constructed for Germanys protection began to unravel. The Reinsurance Treaty lapsed in 1890, and France ended its diplomatic isolation by concluding a military alliance with Russia in 1892. This agreement called for the two to work in concert if one was attacked by a member of the Triple Alliance. A Place in the Sun and the Naval Arms Race An ambitious leader and the grandson of Englands Queen Victoria, Wilhelm sought to elevate Germany to equal status with the other great powers of Europe. As a result, Germany entered the race for colonies with the goal of becoming an imperial power. These efforts to obtain territory overseas brought Germany into conflict with the other powers, especially France, as the German flag was soon raised over parts of Africa and on islands in the Pacific. As Germany sought to grow its international influence, Wilhelm began a massive program of naval construction. Embarrassed by the German fleets poor showing at Victorias Diamond Jubilee in 1897, a succession of naval bills were passed to expand and improve the Kaiserliche Marine under the oversight of Admiral Alfred von Tirpitz. This sudden expansion in naval construction stirred Britain, who possessed the worlds preeminent fleet, from several decades of splendid isolation. A global power, Britain moved in 1902 to form an alliance with Japan to curtail German ambitions in the Pacific. This was followed by the Entente Cordiale with France in 1904, which while not a military alliance, resolved many of the colonial squabbles and issues between the two nations. With the completion of HMS Dreadnought in 1906, the naval arms race between Britain and Germany accelerated with each striving to build more tonnage than the other. A direct challenge to the Royal Navy, the Kaiser saw the fleet as a way to increase German influence and compel the British to meet his demands. As a result, Britain concluded the Anglo-Russian Entente in 1907, which tied together British and Russian interests. This agreement effectively formed the Triple Entente of Britain, Russia, and France which was opposed by the Triple Alliance of Germany, Austria-Hungary, and Italy. A Powder Keg in the Balkans While the European powers were posturing for colonies and alliances, the Ottoman Empire was in deep decline. Once a powerful state that had threatened European Christendom, by the early years of the 20th century it was dubbed the sick man of Europe. With the rise of nationalism in the 19th century, many of the ethnic minorities within the empire began clamoring for independence or autonomy. As a result, numerous new states such as Serbia, Romania, and Montenegro became independent. Sensing weakness, Austria-Hungary occupied Bosnia in 1878. In 1908, Austria officially annexed Bosnia igniting outrage in Serbia and Russia. Linked by their Slavic ethnicity, the two nations wished to prevent Austrian expansion. Their efforts were defeated when the Ottomans agreed to recognize Austrian control in exchange for monetary compensation. The incident permanently damaged the already tense relations between the nations. Faced with increasing problems within its already diverse population, Austria-Hungary viewed Serbia as a threat. This was largely due to Serbias desire to unite the Slavic people, including those living in the southern parts of the empire. This pan-Slavic sentiment was backed Russia who had signed a military agreement to aid Serbia if the nation was attacked by the Austrians. The Balkan Wars Seeking to take advantage of Ottoman weakness, Serbia, Bulgaria, Montenegro, and Greece declared war in October 1912. Overwhelmed by this combined force, the Ottomans lost most of their European lands. Ended by the Treaty of London in May 1913, the conflict led to issues among the victors as they battled over the spoils. This resulted in the Second Balkan War which saw the former allies, as well as the Ottomans, defeat Bulgaria. With the end of the fighting, Serbia emerged as a stronger power much to the annoyance of the Austrians. Concerned, Austria-Hungary sought support for a possible conflict with Serbia from Germany. After initially rebuffing their allies, the Germans offered support if Austria-Hungary was forced to fight for its position as a Great Power. The Assassination of Archduke Franz Ferdinand With the situation in the Balkans already tense, Colonel Dragutin Dimitrijevic, head of Serbias military intelligence, initiated a plan to kill Archduke Franz Ferdinand. Heir to the throne of Austria-Hungary, Franz Ferdinand and his wife Sophie were intending to travel to Sarajevo, Bosnia on an inspection tour. A six-man assassination team was assembled and infiltrated into Bosnia. Guided by Danilo Ilic, they intended to kill the archduke on June 28, 1914, as he toured the city in an open-topped car. While the first two assassins failed to act when Franz Ferdinands car passed by, the third threw bomb which bounced off the vehicle. Undamaged, the archdukes car sped away while the assassin was captured by the crowd. The remainder of Ilics team was unable to take action. After attending an event at the town hall, the archdukes motorcade resumed. One of the assassins, Gavrilo Princip, stumbled across the motorcade as he exited a shop near the Latin Bridge. Approaching, he drew a gun and shot both Franz Ferdinand and Sophie. Both died a short time later. The July Crisis Though stunning, Franz Ferdinands death was not viewed by most Europeans as an event that would lead to general war. In Austria-Hungary, where the politically moderate archduke was not well-liked, the government elected instead to use the assassination as an opportunity to deal with the Serbs. Quickly capturing Ilic and his men, the Austrians learned many of the details of the plot. Wishing to take military action, the government in Vienna was hesitant due to concerns about Russian intervention. Turning to their ally, the Austrians inquired regarding the German position on the matter. On July 5, 1914, Wilhelm, downplaying the Russian threat, informed the Austrian ambassador that his nation could count on Germany’s full support regardless of the outcome. This blank check of support from Germany shaped Viennas actions. With the backing of Berlin, the Austrians began a campaign of coercive diplomacy designed to bring about a limited war. The focus of this was the presentation of an ultimatum to Serbia at 4:30 PM on July 23. Included in the ultimatum were ten demands, ranging from the arrest of the conspirators to allowing Austrian participation in the investigation, that Vienna knew Serbia could not accept as a sovereign nation. Failure to comply within forty-eight hours would mean war. Desperate to avoid a conflict, the Serbian government sought aid from the Russians but were told by Tsar Nicholas II to accept the ultimatum and hope for the best. War Declared On July 24, with the deadline looming, most of Europe awoke to the severity of the situation. While the Russians asked for the deadline to be extended or the terms altered, the British suggested a conference be held to prevent war. Shortly before the deadline on July 25, Serbia replied that it would accept nine of the terms with reservations, but that it could not allow the Austrian authorities to operate in their territory. Judging the Serbian response to be unsatisfactory, the Austrians immediately broke off relations. While the Austrian army began to mobilize for war, the Russians announced a pre-mobilization period known as â€Å"Period Preparatory to War. While the foreign ministers of the Triple Entente worked to prevent war, Austria-Hungary began massing its troops. In the face of this, Russia increased support for its small, Slavic ally. At 11:00 AM on July 28, Austria-Hungary declared war on Serbia. That same day Russia ordered a mobilization for the districts bordering Austria-Hungary. As Europe moved towards a larger conflict, Nicholas opened communications with Wilhelm in an effort to prevent the situation from escalating. Behind the scenes in Berlin, German officials were eager for a war with Russia but were restrained by the need to make the Russians appear as the aggressors. The Dominoes Fall While the German military clamored for war, its diplomats were working feverishly in an attempt to get Britain to remain neutral if war began. Meeting with the British ambassador on July 29, Chancellor Theobald von Bethmann-Hollweg stated he believed that Germany would soon be going to war with France and Russia, as well as alluded that German forces would violate Belgiums neutrality. As Britain was bound to protect Belgium by the 1839 Treaty of London, this meeting helped push the nation towards actively supporting its entente partners. While news that Britain was prepared to back its allies in a European war initially spooked Bethmann-Hollweg into calling on the Austrians to accept peace initiatives, word that King George V intended to remain neutral led him to halt these efforts. Early on July 31, Russia began a full mobilization of its forces in preparation for war with Austria-Hungary. This pleased Bethmann-Hollweg who was able to couch German mobilization later that day as a response to the Russians even though it was scheduled to begin regardless. Concerned about the escalating situation, French Premier Raymond Poincarà © and Prime Minister Renà © Viviani urged Russia not to provoke a war with Germany. Shortly thereafter the French government was informed that if the Russian mobilization did not cease, then Germany would attack France. The following day, August 1, Germany declared war on Russia and German troops began moving into Luxembourg in preparation for invading Belgium and France. As a result, France began mobilizing that day. With France being pulled into the conflict through its alliance to Russia, Britain contacted Paris on August 2 and offered to protect the French coast from naval attack. That same day, Germany contacted the Belgian government requesting free passage through Belgium for its troops. This was refused by King Albert and Germany declared war on both Belgium and France on August 3. Though it was unlikely that Britain could have remained neutral if France was attacked, it entered the fray that next day when German troops invaded Belgium activating the 1839 Treaty of London. On August 6, Austria-Hungary declared war on Russia and six days later entered into hostilities with France and Britain. Thus by August 12, 1914, the Great Powers of Europe were at war and four and a half years of savage b loodshed were to follow.

Directors are legally responsible to the shareholders and must Essay

Directors are legally responsible to the shareholders and must prioritise their interests - Essay Example what a court may consider is in the interests of the company but also introduces the new concept of enlightened shareholder value (Re Smith & Fawcett). It has been argued that the English company law inched closer to, but has not firmly adopted the stakeholder theory. Thus, the test in s.172 remains subjective because what mainly constitutes the success of the company depends on the director’s good faith judgment which may not be objective. It appears that there are no objective criteria in s.172 against which the actions of directors can be assessed. Therefore, it becomes very difficult to prove a breach of this duty. At common law, the objective considerations were introduced by the courts to supplement the subjective test. For instance, in Charterbridge Corp Ltd v Lloyds Bank Ltd, the courts considered whether an intelligent and honest director could in the whole of the circumstances reasonably believe the transaction to be for the benefit of the company as a whole. However, Section 172 makes no reference to this objective consideration in view of the significant role of common law rules in the interpretation and application of the codified duties (s.170(3) and (4). Keay (2007) argues that it is most likely that the courts would conside r the objective test in assessing directors’ actions in any given scenario. There are quite a number of theories the questions the main interests that are supposed to guide the operations of the company. For instance, the traditional approach in the UK is the shareholder value principle (or shareholder primacy), which stipulates that a company should be run for the wealth maximization of its shareholders above those of other parties such as customers and suppliers. For instance, the directors have a duty to act in the interests of the company (Percival v Wright), which are interpreted as the best interests of present and future shareholders (Hutton v West Cork Railway Company). The shareholder value theory states that

Critical Business Ethics In Global Workplace Human Relations Coursework - 1

Critical Business Ethics In Global Workplace Human Relations - Coursework Example d develop ethical principles and guidelines for their employees, where ethics involve the standards on what is right and what is wrong conduct (Renz 2010). However, in the global setting it is more complex to decide what is good or what bad conduct is. In actuality, it is a firm’s social responsibility that comes into debate at this juncture. Over the past decade, there have been numerous ideas presented about the appropriate mode of ethical conduct in global business firms in a global setting. Immense interest in topics such as improper treatment of workers, faulty products that lead to consumer endangerment or inconvenience damage to the environment, as well as ethical conduct issues among countries, organizations, and individuals. However, the heightened sensitivity in the matter and the increasing global competition has created quite the difficult management situation for firms all over the globe. On the other hand, globally active firms, now more than ever, must devise strategies that will ensure their organizations’ are not in the crossfire arising from the increasing focus on ethical conduct. Additionally, firms must develop strategies that carry out additional costs arising as a result of implementation of global ethical standards. The purpose of this paper is to discuss in detail the ethical behavior of firms, especially those that are active globally. The paper unfolds as three sections: First, introduction to the matter in hand. Later, a discussion of the various ethical frameworks in relation to the Credit Suisse case. In the third and final section, a conclusion and personal comments regarding the matters discussed. Ethics can be defined simply as the guiding principles that assist us determine what is right and what is wrong. These guiding principles are the parameters by which the business organizations operate. Ethical behavior implies that individuals behave in the manner acceptable by the organization and society as a whole (Bopp & Smith

1). Produce a 500 - 600 word account of an incident from your Essay

1). Produce a 500 - 600 word account of an incident from your experience that provides an example, or examples of communication processes. 2). Then write an ess - Essay Example This made Chen a sort of pariah at school, often subjected to ridicule as he did such things as taking off his shoes when entering a room or squatting on the floor even when there are chairs around. No one has exactly told Chen to his face that he was odd, but the snickering behind his back did not escape unnoticed and this made him very insecure and hostile of his surroundings. Chen and I are classmates at one of the courses he is taking and my heart goes out to him every time I see him between classes, alone and looking miserable in a corner but showing no inclination to give himself a social life on campus. Eventually, I decided to talk some sense into him, intending to persuade him that his education in globalization will not be complete if he continued keeping his distance from other people. In the process, I expected a gain a new friend. I saw the opportunity to open the conversation with Chen when I caught his eye one day as he looked up from the book he was reading on a bench at the school playground. This is more or less how I started the conversation: â€Å"All of the school notice that you keep to yourself all the time. We wish to make friends with you to make your stay in this school worthwhile; don’t you want us to be your friends, too? From the school records, I understand that you’re studying here because of a long-term goal to make good in international business. That kind of business pursuit requires that you be good at dealing with all kinds of people, you know.† After some hesitation, Chen bowed and responded: â€Å"All of you seem to be nice people, but I didn’t come here to socialize, sorry. And we Chinese deal with people our own way.† He ended the conversation then and there, indicating that I failed to communicate my intended message to him. The way the conversation turned out, I made a new enemy instead of gaining a friend. In retrospect, I realize that my choice of language and approach was at fault since I sounded

Significance of the Ecosystem Services Essay Example | Topics and Well Written Essays - 500 words - 7

Significance of the Ecosystem Services - Essay Example These are economic decisions and depend on both the implicit and explicit societal values. In this article, I will give examples of ecosystem services, biodiversity concepts and how the ecosystem is considered from economics, ethics and science points of view. Examples of ecosystem services include regulation of climate. This is one of the most significant services of the ecosystem on a worldwide and European scale. European ecosystem functions as a significant role in the regulation of climate because the terrestrial ecosystem in Europe resembles a carbon sink in approximately 12 percent of the carbon emissions that humans emit to the atmosphere. Another example of ecosystem service is the purification of water. Both the soil organisms and vegetation have profound effects on improvements of water. Vegetation is a critical factor that helps in control of floods. Wetlands and forests often offer water at a lower cost compared to manmade facilities such as water treatment plants. Anoth er example of ecosystem services is the regulation of pests and diseases (Wilson 17). This occurs because of the actions of parasites and predators and also defense mechanisms of their prey. One example of this control of pests and diseases is the offered by insectivorous birds that are available in the farmlands. Biodiversity concepts refer to variability and variety of living organisms. Biodiversity is significant in the functioning of the ecological systems. Ecosystem services represent the ecological process that humans may benefit. These processes function on an infinite number of scales. A number of ecosystem services ensure that their productivity in agriculture, including pollination, soil formation and pest control (Wilson 34). Biodiversity concepts may include diseases and pests control. Predators that prey on the parasites and insects control plant diseases.

Contraception Essay Example | Topics and Well Written Essays - 250 words - 1

Contraception - Essay Example Religion and culture plays an important role in following strict parameters for entering into the relationship. Unplanned pregnancy do not have a bright fate and may culminate into abortion which has serious repercussions at the later stages of life. Adopting contraceptive means at the early stages of life is also against the ethics and nature as it disconnects sex from reproduction and bring serious health implications. Mass population control is a kind of sterilization and it may lead to dishonest behavior, as the partners seek sexual relationship elsewhere. Therefore advocates against the contraception finds it equivalent to abortion. On the other hand contraception provides the liberty to the women to control her own body and keep the population low. It keeps the family small and also prevents the unwanted pregnancies. Contraception aids in better facilities for all the family members, they can devote quality time with each other and thereby contribute to the progress and development of the children. This prevents competition for food and space. It is the best means to control the population as every human beings must bear ethics towards the planet and mother Earth, by giving birth to too many children the health of the female becomes a serious matter of great concern. Less children in the family lessens the financial burden and also the burden on the earning members to the family and parents could afford for better education and better life and facilities to their wards. It is the means which must gain ethical consideration as it is for the cognitive development of the family, the smallest unit of the society and hence of the society and the nation. It is a means that brings gender equality and aids in demographic advantage. It is a means that brings us close to the nature and prevent environmental hazards. Thus contraception must be promoted by the government of all the nations to save the environment form burden which

New Product Development is the Key to Apple's Marketing Success Coursework - 1

New Product Development is the Key to Apple's Marketing Success - Coursework Example One of the most innovative products of Apple was iPhone which was considered as one of the best-selling products. The business operations of Apple are expanded in almost all geographical nations (Apple Inc, 2012). Apple’s Strategies Apple seeks to apply its idea of being a digital heart in the field of electronic products because customers demand stylish and cohesive digital devices. Apple always attempts to distinguish itself from other brands so that it can put premium rates on their products. The business strategy for Apple is to find the accurate equilibrium between customer satisfactions and cost because this blend is vital for raising the product price for customers and thereby increasing profitability. In the consumer electronics market, Apple is known for premium price products because it invests huge amount of funds on new product development and innovation activities. The product differentiation is a major competitive strength for Apple as it can successfully increas e the perceived value of its products and help to generate more revenue in spite of premium cost (Iiiev & et. al, 2004). Quality products and innovation through wide practise of research and development (R&D) is the other key reason behind the success of Apple in the market. The main objective of Apple is to expand its customer base (Iiiev & et. al, 2004). Product Portfolio of Apple Traditionally, Apple manufactured and developed software applications and computer products; however, after the introduction of iPod as one of the preferable MP3 players for people, several new product lines have been included in product portfolio of Apple. The old and new product portfolios of Apple are described in following table: Product Portfolio Product Lines Software and Computer iOS, Mac Operating System, Professional and Business Application Programmes, Personal Computer Hardware Products Desktop Computer, Laptop Computer, iMac, Mac Pro, Mac Mini, iBook iPhone Mobile Phones, iPods, Digital Devic es, iPads iTunes Music, Applications, Bookstore iCloud Cloud Services Application Software iLife, iWork Display and other Fringe Products Printers, Storage Devices, Digital Cameras, Apple TV Source: (EDGAR Online, 2011). People Apple has a bureaucratic organisational structure where CEO is in the top position of hierarchy. The CEO and Vice Presidents gather reports about company’s business operations from both line and staff managers. Apple is highly dependent on manufacturing representatives on whom it has no direct influence. The positions of Apple in the organisational hierarchy are described below: Source: (Apple Inc., 2012). New Product Development New product development is all about introducing new product in any industry. It is a process for developing a product in order to certify progress or survival in the market. The aim of new product development is to strengthen or transform the strategic direction. An effective new product can help an organisation to add a new product line under the product portfolio (Takeuchi & Nonaka, 1986). Reasons for Launching New Product in the Market Developing new product signifies relocating or

Contraception Essay Example | Topics and Well Written Essays - 250 words - 1

Contraception - Essay Example Religion and culture plays an important role in following strict parameters for entering into the relationship. Unplanned pregnancy do not have a bright fate and may culminate into abortion which has serious repercussions at the later stages of life. Adopting contraceptive means at the early stages of life is also against the ethics and nature as it disconnects sex from reproduction and bring serious health implications. Mass population control is a kind of sterilization and it may lead to dishonest behavior, as the partners seek sexual relationship elsewhere. Therefore advocates against the contraception finds it equivalent to abortion. On the other hand contraception provides the liberty to the women to control her own body and keep the population low. It keeps the family small and also prevents the unwanted pregnancies. Contraception aids in better facilities for all the family members, they can devote quality time with each other and thereby contribute to the progress and development of the children. This prevents competition for food and space. It is the best means to control the population as every human beings must bear ethics towards the planet and mother Earth, by giving birth to too many children the health of the female becomes a serious matter of great concern. Less children in the family lessens the financial burden and also the burden on the earning members to the family and parents could afford for better education and better life and facilities to their wards. It is the means which must gain ethical consideration as it is for the cognitive development of the family, the smallest unit of the society and hence of the society and the nation. It is a means that brings gender equality and aids in demographic advantage. It is a means that brings us close to the nature and prevent environmental hazards. Thus contraception must be promoted by the government of all the nations to save the environment form burden which

Act 2- Proctors house Essay Example for Free

Act 2- Proctors house Essay The crucible is set in the early 1920s in a place called Salem in Massachusetts America. The story is based on the problem of witchcraft; to be a witch or warlock in those days was unforgivable. The people living in Salem were all strict Puritans and anything un-natural was said to be wrong. Anyone with any evidence of another being in contact with the devil was immediately taken to court for a case, they could be imprisoned for many years or worse killed. As you can imagine this arose a great deal of problems including peoples greed or jealousy taking over their moral beliefs. People would accuse others to get what they wanted e.g. land. Act 2- Proctors house. Role of Elizabeth  Elizabeth- What keeps you so late? Its almost dark.  At this point in the story Elizabeth still has a slightly higher status than her husband, and has done for quite a while this is because he is the one that has sinned and still needs to watch his step if he wants to keep her as his wife. As she walks in from singing to the children, she will be looking at her husband at first, then look out side swiftly when she says Its almost dark. She asks a question about his work to be polite, not necessarily interested so will be busy with something on the table, e.g. a candle stick. When she has to respond to Proctor asking if the boys are asleep she will look up from what she is doing and answer while walking quickly over to the fireplace. She answers vaguely to Proctors wishing for a fair summer.  When Proctor asks if she is well today She turns around with the plate of his food and smiles kindly and responds I am Although not returning the question. She then nods at the plate and tells him it is rabbit. She then pulls out a chair and sits by him watching him sit down to eat. Her eyes never leave him apart from to look at the rabbit describing how painful it was for her to strip her. While she watches him taste it, there is a look of slight anticipation on her face to see his respond. She is still sitting up right facing him, perfect posture. It is at this point that their statuses are equal, she wants praise from him. Which when she gets she blushes and smiles, but asks for more; so asks- its tender? Maybe leaning slightly further forward, closing the distance that is between them. After proctor tells her that he means to please her, the eye contact becomes more intense for a split second but soon disappears. Her facial expression is of fake happiness maybe even slight sadness. As she replies she looks at Proctor for the beginning of the line I know it but then looks down when she says John. Indicating it is very hard for her to say. When Proctor tries to kiss her she does not lean in towards it but sits very still and up right in her chair, looking away. She receives it but does not return it. After he has sat down she continues to look at him, which is when he sullenly says Cider. In a thanking sort of way, for changing the subject she quickly stands replying Aye! The subject back onto the farm, Elizabeth still shows that there is something still annoying her. She walks quickly back with the cider and places it by him, and sits back down. Proctor then introduces the idea of flowers in the house, she answers quickly, and looking around, hands on the table and feet perfectly together on the floor. She says that she has forgotten, but this is not top on her list, so says it rather quickly, with the air of not really caring about it. Proctor then suggests that they go on a walk together one day to look at the flowers; he finishes the sentence with saying how beautiful Massachusetts is in the spring. Elizabeth only responds to this, not the walk through the wood together. Her answer is short and quick, and as she says it has a knowing look upon her face and nods slightly but it is obvious that she doesnt care and this is not what she is thinking about at the moment. There is a pause and she continues to watch him for a short while, with a look of enquiry and un-knowing on her face. When he does not say anything she gets up and picks up his plate and cutlery. She does this briskly not saying a word. She stands by the basin, after placing the plate and cutlery in it. She has her back to him and does not move, but waits.  Proctor then says I think youre sad again, are you? She doesnt reply immediately and still doesnt turn round, as if holding back words. She soon does however and when she speaks it is slowly, this is because she does not want an argument so she makes it look as if she is the one in the wrong asking herself a stupid question in her mind. This immediately lowers her status ever so slightly. His reply is harsh and sudden, which doesnt strike her, if anything makes her slightly more frightened, she rubs her hands around each other nervously but subtly, yet still stands tall. You did speak of going, earlier this week. As if reminding him, that she had good reason to think that he might have gone Salem that day.  When she tells him that Mary Warren had gone that day, she looks at him directly; she still does not move her body though, she announces it very clearly. After his reply she has weakened a little, she knew that by telling him this it would get to him, now she can see that he is holding back from shouting. This still gives her the upper status. So when she says I couldnt stop her. She shakes her head slightly but still watches him. She then goes on to say how Mary Warren frightened all her strength and power away from her, at this she will step forward, its now that she begins to use her body to express, all the way so far her torso has stayed upright. As she steps forward she looks Proctor in the eye. And she moves her arms forward, which shows her weakness breaking through.  It is a mouse no more. I forbid her to go, and she raises up her chin like the daughter or a prince and says to me, I must go to Salem, Goody Proctor, I am an official in the court!